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For GMP manufacturing this site is equipped for mainly solid-phase synthesis and is designed to handle lot sizes typically up to 1 kg

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654 Of note, astrocyte-specific deletion of mutant huntingtin in mice globally expressing this gene eased disease symptoms and delayed its progression, indicating a role for astrocytes in the pathophysiology of the disease

Data from Optums de-identified Clinformatics Data Mart Database (Optum CDM) are compliant with the Health Insurance Portability and Accountability Act of 1996, and the study was performed in accordance with the Helsinki Declaration of 1964 and its later amendments